BACKGROUND:Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients.Several professional transplant societies and publications have generated skepticism of the generic approval process.Three ma
Human adenoid cystic carcinoma (ACC) is characterized by diffused invasion of the tumor into adjacent organs and early distant metastasis.Anoikis resistance and epithelial mesenchymal transition (EMT) are considered prerequisites for cancer cells to metastasize.Exploring the relationship between these processes and their underlying mechanism of act
Summary: During rectangular barn quilt patterns cytokinesis, a contractile ring consisting of unbranched filamentous actin (F-actin) and myosin II constricts at the cell equator.Unbranched F-actin is generated by formin, and without formin no cleavage furrow forms.In Caenorhabditis elegans, depletion of septin restores furrow ingression in formin m
This study was undertaken to create an Asiatic black bear (Ursus thibetanus; ABB) ethogram during hibernation and to describe the time budget of hibernating behaviours in ABB.Seven captive adult ABB were included in the study and jordan 12 nubuck began hibernation between October and December.Data were collected for three consecutive years (2013-20